CMU gets grant to study HIV
Sci/Tech |
AIDS is one of the most devastating pandemics to have been recorded in history, affecting humans of all ages and from all parts of the world. Recently, the World Health Organization estimated that AIDS has killed more than 25 million people since it was first recognized. It is no wonder that scientists around the world are working quickly to find a cure for such a destructive virus.
Judith Klein-Seetharaman is one such scientist who is active in HIV research. She currently is teaching at Royal Holloway, University of London, where she is a neuroscience professor and head of the Center for Biological Sciences. She was a research scientist in the Language Technologies Institute at Carnegie Mellon University, where she studied computational biolinguistics, and her research on HIV will also be conducted at Carnegie Mellon.
Many organizations around the world have noted the damage caused by infections like AIDS and tuberculosis, and have been supporting research for their cure. Recently, the Bill and Melinda Gates Foundation awarded 104 research grants to explore unconventional and novel methods to improve global health.
The grants are worth $100,000 each, and were awarded to scientists from 22 countries around the world.
Out of nearly 4000 proposals, Klein-Seetharaman’s was selected as one of the 104 to receive the grant. Klein-Seetharaman aims to analyze sequences of signal transduction pathways, which are intercepted by HIV so they do not function as they should. Signal transduction pathways are the signaling mechanisms in a cell that help the cell respond to different stimuli.
HIV interferes with the cellular signaling system causing the host cells to make more copies of HIV. Klein-Seetharaman explained it was similar to the virus hijacking a cell.
As stated in the general project summary, “[Klein-Seetharaman’s research] aims to use advanced computational methods to predict parallel pathways that can be found and used to circumvent the points of HIV interception.”
Klein-Seetharaman explained, “Predicting the human proteins that interact with HIV and predicting the human proteins that interact with other human proteins are two biological functions that are critical to our project.”
Using computational tools, she will find new signal transduction pathways associated with human proteins and study how HIV and other pathogens interact with these proteins.
Klein-Seetharaman wants to apply algorithms that were produced from earlier studies of molecules to HIV, focusing on certain membrane proteins. She also hopes to find alternate pathways which have the same endpoint as those affected by HIV. Activating these may counter the HIV-affected pathways.
She plans to use methods developed for understanding human languages to understand molecular language. This idea was started in 2001 when the Human Genome Sequence was published, and Klein-Seetharaman and a team of researchers decided to link genes to their protein functions.
She explained, “We proposed that we can map the gene sequences to protein structure and function in the same way words map to meaning in human language.”
This research is very different from previous research because, as Klein-Seetharaman said, “It is general.” She explained, “We will find novel drug targets using a new approach generally referred to as systems biology — instead of restricting ourselves to a few proteins, we analyze the whole set of proteins.”
Klein-Seetharaman aims at targeting the way HIV interacts with cells, and not just manipulating one protein in the pathway to prevent HIV infection. Through her research, she hopes to find a list of human proteins that will be novel anti-HIV drug targets.
Dr. Tachi Yamada is the president of the Gates Foundation’s Global Health Program. “I congratulate each individual who took the initiative to share their idea with us to help fight the world’s most serious diseases,” he said in an article from Medical News Today. “The number of creative approaches we received exceeded our highest aspirations.”
The resources at Carnegie Mellon have been valuable for conducting research. The large variety of expertise that Carnegie Mellon has to offer is very beneficial to the project. Klein-Seetharaman noted the importance of collaboration and the sharing of ideas. “Our collaborations with computer scientists at Carnegie Mellon University are important components of the project,” she said.
Klein-Seetharaman is hopeful that her project and many others will be beneficial for health in developing countries, and will be ready for real-world applications. “I’m very excited. We found something that’s held relevant. It’s nice to support the connection from fundamental to applied research.”
THE CURE for HIV/AIDS.......AMBUSH
THE IDEA that AMBUSH cures AIDS
is being proven by the more than 400 individuals who have taken a dose of 60 ml three times daily for 21 days. The result is that AMBUSH 'KILLS' the virus by causing the protein envelope to rupture and the viral particles are discarded by the white blood cells. AMBUSH is able to 'KILL' the virus that are 'hiding' in the lymph system by its 'natural radioactive' properties. This process allows the body to 'return to normal health' with a corresponding immunity to that or those strains of the virus.
What is AMBUSH ?
AMBUSH is a radioactive isotope of uranium that is found in the 'palm' plant of which there are more than 3000 species. When ingested, AMBUSH causes the body temperature in the trunk area to rise to about 102 degrees when the individual is sleeping. The preparation takes four hours per batch, which is then given to the individuals for consumption 60 ml three times daily for 21 days. AMBUSH is a herbal preparation in this form but it contains an active ingredient which is a 'NEW' crystalline substance, a drug from the 'palm plant' similarly to ASPIRIN originating from the willow tree bark
RESULTS:
After 21 days on AMBUSH, ALL the individuals experienced a decrease in viral load to undetectable, an increase in cd4, increase in RBC, an improvement in general health such as more color to the face, decrease in Buffalo hump, an increase in gluteal muscles, a decrease to having no joint pains whereby individuals can bend to touch their toes, and walk up steps are but a few examples. There is also a dramatic increase in their sexual appetite beginning after the first week of therapy
DISCUSSION:
In any plant concoction such as percolated 'tea', there are 30-40,000 compounds, whi ch would take the scientific community twenty years to isolate one particular ingredient if they knew what they were looking for. The LORD GOD has given me seven steps to isolate the active ingredient, which is soft and metallic in nature and has a carbon- uranium-sulfur-(classified)-phentolamine configuration or structure. This is similar to Federick Kekule and the discovery of the benzene ring where he dreamt the structure.
As an antiviral and 'natural radioactivity' producing agent, AMBUSH is also effective against leukemia, lupus and HPV. Here I am saying that I have 'GIVEN' AMBUSH in the same 'strength' and dosage to patients with leukemia, lupus and HPV. A 35 year old male with HIV found it difficult to impossible to urinate was put on 'green tea' and water while the doctors contemplated prostrate surgery. One of the doctors gave him my number , I sent him a supply of AMBUSH an d he has not been given any more ARV's, since taking AMBUSH 18 months ago, is in 'good' health and has expressed a willingness to be examined by HIV investigators like many others who have taken AMBUSH.
I have sent this 'IDEA' to most HIV research agencies, scientist of the field, universities, hospitals, clinics, politicians and news agencies to which it is REJECTED because the name of THE LORD GOD is mentioned. He has steered me scientifically through the processes such as which plant and how to produce the active ingredient. What are the odds of a Florida Pharmacist picking a plant would contain the CURE for HIV/AIDS ?
I have never charged any of the people for their supply of AMBUSH but a life saving has been spent on the project with NO renumeration from any sources because AMBUSH falls outside the walls of modern medicine and research.
PROPOSAL:
My proposal is that I PROVE that AMBUSH CURES HIV/AIDS by giving it to a number of END-STAGE or DRUG-RESISTANT people and the scientific community watches their recovery. This proposal addresses the problem in that I have already outlaid the results to be obtained.
This IDEA is unconventional in that the scientific community has rejected AMBUSH because I say it is GOD given. Secondly if I wrote it according to certain standards, then it might be peer reviewed. However, THE LORD GOD has also shown me that there are five enzyme systems associated with the virus, reverse transcriptase, protease, fusion and two more of which causes the virus to be AIRBOURNE. This means that without DIVINE intervention mankind and ALL warm- blooded mammals will be extinct in a number of years.
The PROOF of what I am saying is found in scientific papers wherein it is found that when the protease cuts the viral strands, it cuts it at DIFFERENT lengths EVERY time, to which it should always be a valine at the end but is a different amino acid every time. This is why it is IMPOSSIBLE to produce a VACCINE.
Since this is NOT a hypothesis but there are about 400 individuals who have taken AMBUSH, here lies a vast area in which to check, recheck and confirm that AMBUSH CURES AIDS. Let it be mentioned that during the HIV reproductive cycle, reverse transcriptase converts viral RNA into DNA compatible to human genetic materials. Thus the human DNA has been 'hijacked' and since each person has a DIFFERENT DNA, then the new viral copy is unique to that person which shows that each individual has a DIFFERENT STRAIN of the virus. Consider two HIV positive people swapping viral strains and increasing its complexity with multiple partners.
It can also be proposed that they be revisited as proof that the strain or strains that they had were 'killed' at the time of taking AMBUSH considering that a person can catch as many different strains as there are people who are infected by HIV.
I am also willing to work with the scientific community in identifying those individuals who took AMBUSH and wish to be identified with this process notwithstanding that some are stigmatized while others are jubilant,
Once AMBUSH is verified as being able to accomplish that which is aforementioned then the next stage might be the natural and artificial synthesis of the substance.
Finally, if this is accepted or not, believed or not, THE LORD GOD always wins and this is the heavenly truth to which AMBUSH was divinely given to mankind for the CURE of HIV/AIDS and it will be here forever. Apostle Shada Mishe.
Here is a video taped presentation that I gave at t he Martin Luther King library in Washington
http://www.youtube.com/watch?v=8V53D1w__Po
http://www.youtube.com/watch?v=vPwuwlVBOV0
http://www.youtube.com/watch?v=ZejptOwMTzQ
http://www.youtube.com/watch?v=CqcTgIAhrhc
http://www.youtube.com/watch?v=f7HPKcT_iwY
http://www.youtube.com/watch?v=W9iQfgiYAnw
http://www.youtube.com/watch?v=i3RzRS6tJDM
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